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KMID : 0358320080490020127
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Korean Journal of Urology
2008 Volume.49 No. 2 p.127 ~ p.133
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The Effect of the Serum Cholesterol Level on the Clinicopathologic Characteristics of Prostate Cancer
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Sung Woo-Seuk
Jeon Seung-Hyun
Chang Sung-Goo
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Abstract
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Purpose: We assessed the relationship between the serum cholesterol level and the clinicopathologic characteristics of prostate cancer patients who had undergone a radical retropubic prostatectomy.
Materials and Methods: We enrolled 70 prostate cancer patients who had relevant data available for this study. All of the patients had their serum cholesterol level checked at least three times for a month preoperatively. We divided them into three groups according to: 1) a mean preoperative cholesterol level less than 180mg/dl, 2) between 180mg/dl and 200mg/dl, and 3) more than 200mg/dl. The serum cholesterol levels and other clinicopathologic characteristics were then compared and analyzed. The clinicopathologic findings included the pathologic T stage, Gleason score, prostate-specific antigen(PSA) and the other pathologic findings that included perineural invasion, vascular invasion, lymphatic invasion and capsular invasion. All the data was retrospectively collected from the patients’ medical records.
Results: The mean cholesterol level was 181.1±4.1mg/dl. There was a statistically significant difference in the incidence of perineural invasion among these three groups according to the cholesterol level, with linear correlation(p=0.015). This correlation was more significant among the T2 patients or the patients with a total PSA value of 4ng/dl to 10ng/dl. Furthermore, the preoperative serum cholesterol level was significantly affected by the pathologic finding of perineural invasion(p=0.024, odd ratio=3.565).
Conclusions: There was a direct correlation between the increase incidence of perineural invasion with the increased preoperative serum cholesterol level for prostate cancer patients who had undergone radical prostatectomy. (Korean J Urol 2008;49:127-133)
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KEYWORD
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Prostatic cancer, Cholesterol, Prostatectomy
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